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Most often, dermatologists make a diagnosis based on the clinical picture of the disease, but if there is any doubt, the patient is sent for histological examination of the affected area of ​​the dermis. Unfortunately, it is still impossible to get rid of this unpleasant illness forever, but it is possible to achieve stable remission through adequate treatment. First of all, the treatment of Darier's disease includes taking drugs containing a large amount of vitamin A.

In order to reduce possible side effects, hepatoprotectors and vitamins of other groups are also prescribed to the patient. Along with drug treatment, cryotherapy, laser treatment, physiotherapy are also widely used.procedures and burning of baclofen pills tissues with current, or diathermocoagulation. Hormone therapy is prescribed only in the most severe cases, when the patient's endocrine system suffers.

Follicular vegetative dyskeratosis (Dariaer's disease) is a hereditary pathology of an autosomal dominant type with varying degrees of manifestation of a defective gene. The disease is accompanied by dyskeratosis (keratinization of epidermal cells). First, small spherical papules appear on the skin, then flaky spots with a crust on the surface, merging into plaques. Most often they appear on the face, scalp, chest, back. Often the disease is accompanied by a secondary infection, men and women, adults and children are ill. Treatment is symptomatic with a favorable prognosis.

Follicular dyskeratosis is a hereditary dermatological disease caused by an anomaly in that part of DNA that is responsible for the production of a protein necessary for the communication of epidermal cells. The disease is passed from generation to generation, often manifesting itself only after 20 years. For the first time, the pathology was studied by J. Darier, a dermatologist from France. In a medical treatise on psorospermia from 1889, he described specific microorganisms, which he designated as the causative agents of the disease.

Darier's disease is chronic and progresses in the warm season, when the skin is exposed to more intense ultraviolet radiation. It requires attention to the skin from those people whose parents are carriers of defective genes. What this or that form of follicular dyskeratosis looks like can be seen in the photos below.

Multiple papules of baclofen pills nature of a grayish-brown color with a diameter of 3-6 mm. They have a spherical shape, dense to the touch, covered with small scales. Localization on the face, scalp, behind the ears, in large folds of the skin, on the chest and back. Gradual fusion of individual papules into verrucous plaques. Small vesicles on the skin, more often - with localization on the neck. White or red longitudinal stripes on the nails, delamination of the nail plates.

The characteristic symptoms of Darier's disease include pathological changes in the skin - thickening and coarsening of the epidermis, as well as peeling of varying intensity. Other typical manifestations can also be identified.

Follicular dyskeratosis is hereditary. The main reason is an abnormal gene in DNA, the main provoking factor is a genetic predisposition. A defective gene prevents the body from assimilating vitamin A, in addition, the activity of producing certain enzymes in the skin tissues decreases, and the amount of zinc decreases. As a result, the process of keratinization of the skin is disrupted. If the parents are the owners of the abnormal gene, in 50% of cases their children will be diagnosed with Darier disease. If a healthy child is born to carriers of such a gene, his children and subsequent generations will no longer have such a pathology. Some scientists believe that the cause of vegetative dyskeratosis in some cases is a lack of vitamin A.

Darier syndrome is inherited, but only appears in adults.

Very rarely, symptoms of the disease can be observed in adolescence. Since no cases of complete recovery are known, treatment of Darier's disease in children does not make sense. However, early diagnosis can achieve remission and avoid complications.

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Diagnosis of Darier's disease.

To establish the diagnosis allows examination and questioning of the patient. The doctor examines the symptoms, clarifies what skin problems the next of kin have. For an accurate diagnosis, he prescribes: Histological examination of damaged skin. General blood analysis. Analysis of urine. Biochemical blood test (AlAT, AsAT, bilirubin, triglycerides, alkaline phosphatase).

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According to the clinical picture, follicular dyskeratosis resembles leukoplakia. It must be differentiated from the following diseases:

Kirle disease. Lichen planus. Pemphigus. Seborrheic dermatitis. Epidermodysplasia verruciform. There are no cases of complete recovery from vegetative dyskeratosis, but timely therapy slows down the pathological process and reduces the risk of complications. The basis of treatment is vitamins A, hepatoprotectors and other vitamins. In summer, vitamin A is not prescribed. In more severe cases, an operation is performed to destroy the neoplasms.

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It is possible to attach a secondary infection (bacterial and fungal etiology). Treatment of the disease is taking vitamin A courses, more effectively - aromatic retinoids. External treatment is of secondary importance. But patients can stop therapy on their own. I have not found anywhere in the literature data on whether this disease is an indication for obtaining a disability group. If anyone has experienced a similar situation, please share your experience. How to cure Darya disease.

DARRIER'S DISEASE is a hereditary autosomal dominant disease characterized by a rash of follicular hyperkeratotic papules, predominantly at the sites of manifestation of seborrhea, prone to confluence and formation of foci with vegetation, especially in the folds.

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The disease was first described in 1889 by the famous French dermatologist Jean Ferdinand Darier (Ferdinand-Jean Darier 1856-1938) under the name vegetative follicular psorospermosis. He mistakenly believed that the causative agent of the disease were microorganisms - psorospermia.